Tobias Opialla

Tobias OpiallaMyoGrad-associated doctoral student 2012-2016
Date and place of thesis defense:
October 12, 2016 in Berlin
Doctoral degree from FU Berlin



Thesis title


Metabolome and proteome based analysis of muscular dystrophies

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Séverine Kunz

Severine KunzMyoGrad doctoral student 2010-2014
Date and place of thesis defense:
October 22, 2014 in Paris
Joint doctoral degree from UPMC, Paris VI and from FU Berlin







MyoGrad Project 6 

PI Berlin: Simone Spuler, MD Prof. – Muscle Research Unit, ECRC, Charité
PI Paris:  Thomas Voit, MD Prof. – Institute of Myology, UPMC, Paris 6

 
Thesis title: Characterization of the sarcolemma in limb-girdle muscular dystrophy

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Joscha Griger

Josha GrigerMyoGrad doctoral student 2010-2015
Date and place of thesis defense:
November 6, 2015 in Berlin
Doctoral degree from FU Berlin






 
MyoGrad Project 4

PI Berlin: Carmen Birchmeier, PhD, Prof. – Max Delbück Center for Molecular
              Medicine

Thesis title: Shp2 functions in postnatal skeletal muscle growth and regeneration

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Antoine Zalc

MyoGrad doctoral student 2010-2014
Date and place of thesis defense:
September 26, 2014 in Paris
Joint doctoral degree from UPMC, Paris VI and from FU Berlin


MyoGrad Project 4

PI Berlin: Carmen Birchmeier, PhD, Prof. – MDC for Molecular Medicine
PI Paris:  Frederic Relaix, PhD, Prof. – Institute of Myology, UPMC, Paris 6

Thesis title: Study of Pax3 and Pax7 functions during the development of the mouse embryo

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Janine Berkholz

Janine BerkholzMyoGrad doctoral student 2010-2015
Date and place of thesis defense:
February 26, 2015 in Berlin
Doctoral degree from FU Berlin








MyoGrad Project 3

PI Berlin: Barbara Munz, MD, Junior Prof. – Department of Physiology, Charité 
PI Paris:  Frédéric Relaix, PhD, Prof. – Institute of Myology, UPMC, Paris 6

Thesis title: The skNAC-Smyd1 complex: a multifunctional regulator of myogenesis?

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Vinko Palada

MyoGrad doctoral student 2013-2017
Date and place of thesis defense:
March 13, 2017 in Berlin
Doctoral degree from FU Berlin

MyoGrad Project 6

PI Berlin: Simone Spuler, MD, Prof. – Muscle Research Unit, ECRC, Charité

Thesis title: Molecular mechanisms of muscle pain associated with myotonic dystrophy type II

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Christopher Polack

Christopher PlackMyoGrad doctoral student 2010-2015
Date and place of thesis defense:
October 15, 2015 in Berlin
Doctoral degree from FU Berlin







MyoGrad Project 7

PI Berlin: Michael Gotthardt, MD, Prof. – MDC for Molecular Medicine
PI Paris:  Ana Ferreiro, MD, PhD – Institute of Myology, UPMC, Paris 6

Thesis title: Function of titin in striated muscles in health and disease

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Susanne Philippi

MyoGrad doctoral student 2010-2014
Date and place of thesis defense:
September 25, 2014 in Paris
Joint doctoral degree from UPMC, Paris VI and from FU Berlin

MyoGrad Project 6

PI Berlin: Simone Spuler, MD, Prof. – Muscle Research Unit, ECRC, Charité
PI Paris:  Luis Garcia, PhD – Université de Versailles Saint-Quentin-en-Yvelines

Thesis title: RNA-based therapies for dysferlinopathies

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Claudia Langhans

MyoGrad doctoral student from 2010-2012
Doctoral student at Charité from 2012-2015
Date and place of thesis defense:
March 27, 2015 in Berlin
Doctoral degree from Charité Universitätsmedizin Berlin, Germany 

MyoGrad Project 2

PI: Jens Fielitz, MD, PhD – Department of Cardiology, ECRC, Charité

Thesis title: Inflammation-induced acute phase response leads to critical ilness myopathy (CIM) - serum amyloid A as early marker

Salyan Bhattarai

MyoGrad doctoral student 2013-2017
Date and place of thesis defense:
March 20, 2017 in Berlin
Doctoral degree from FU Berlin

MyoGrad Project 2

PI Berlin: Eugen Feist, MD, PhD - Department of Rheumatologyand Clinical
               Immunology, Charité

Thesis title: Functional role of ubiquitin proteasome system in idiopathic inflammatory myopathies

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Can Ding

Can Gut DingMyoGrad doctoral student 2011-2015
Date and place of thesis defense:
November 6, 2015 in Berlin
Joint doctoral degree from UPMC, Paris VI and from FU Berlin


 

 
 

MyoGrad Project 1

PI Berlin: Markus Schülke-Gerstenfeld, MD, Prof. – NeuroCure Clinical Research               Center, Charité
PI Paris:  Luis Garcia, PhD – Université de Versailles Saint-Quentin-en-Yvelines
            

Thesis title: The influence of Notch over-stimulation on muscle stem quiescence versus proliferation, and on muscle regeneration  

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Amalia Stantzou

Amalia-Stantzou-swMyoGrad doctoral student 2011-2015
Date and place of thesis defense:
September 29, 2015 in Paris
Joint doctoral degree from UPMC, Paris VI and  fromFU Berlin






MyoGrad Project 1


PI Berlin: Markus Schülke-Gerstenfeld, MD Prof – NeuroCure Clinical
              Research Center, Charité
PI Paris/Versailles: Helge Amthor, MD, Prof. – Université de Versailles                             Saint-Quentin-en-Yvelines

Thesis title: The regulation of murine and human muscle precursors by BMP signalling

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Karima Relizani

Karima-RelizaniMyoGrad doctoral student from 2010-2014
Date and place of thesis defense:
July 7, 2014 in Berlin
Joint doctoral degree from UPMC, Paris VI and from FU Berlin






 MyoGrad Project 1

PI Berlin: Markus Schülke-Gerstenfeld, MD, Prof. – NeuroCure Clinical Research                Center, Charité
PI Paris:   Helge Amthor, MD, Prof. – Université de Versailles Saint-Quentin-
               en-Yvelines

Thesis title: The function of activin receptor IIb signaling in adult skeletal muscle 

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Anna Pakula

Anna PaulaMyoGrad doctoral student from 2010-2015
Date and place of thesis defense:
September 22, 2015 in Berlin
Doctoral degree from FU Berlin


 
 


 
 
MyoGrad Project 5

PIs Berlin: Michael Boschmann, MD – ECRC, Charité
PI Paris:    Pierre Carlier, PhD - Institute of Myology, UPMC, Paris

Thesis title: Muscle metabolism and cyclin A1 in facioscapulohumeral muscular dystrophy-1 (FSHD-1)

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Matthew Thorley

MyoGrad doctoral student 2013-2016
Date and place of thesis defense:
December 7, 2016 in Paris
Joint doctoral degree from UPMC, Paris VI and from FU Berlin

 
MyoGrad Project 5

PIs Berlin: Michael Boschmann, MD – Franz Volhard Clinical Research Center,
                ECRC, Charité and Matthias Selbach, PhD, Prof., Max Delbrück
                Center for Molecular Medicine
PI Paris:    Gillian Butler-Browne, PhD and William Duddy, PhD - Institute of
                Myology, UPMC, Paris

Working Title: The analysis of the dystrophin interactome

 

Apostolos Malatras

MyoGrad doctoral student 2014-2017
Date and place of thesis defense:
December 13, 2017 in Paris
Joint doctoral degree from UPMC, Paris VI and from FU Berlin

 
MyoGrad Project 2

PIs Berlin: Simone Spuler, MD, Prof. – ECRC, Charité
PI Paris:    Gillian Butler-Browne, PhD and William Duddy, PhD - Institute of
                Myology, UPMC, Paris

Thesis title: Bioinformatic tools for the systems biology of dysferlin deficiency

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Christine Schwartz

Christine-Technau-swMyoGrad doctoral student 2012-2016
Date and place of thesis defence:
September 29, 2016 in Berlin
Joint doctoral degree from UPMC, Paris VI and from FU Berlin








MyoGrad project 7


PI Berlin: Simone Spuler, MD, Prof. – Muscle Research Unit, ECRC, Charité
PI Paris:  Gisèle Bonne, PhD – Institut de Myologie, UPMC, Paris 6

Thesis title: Muscle LIM protein and nesprin-1 in mechanotransduction

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Despoina Mademtzoglou

Despoina-Mademtzoglou-swMyoGrad doctoral student 2012-2016
Date and place of thesis defense:
September 2, 2016 in Paris
Joint doctoral degree from UPMC, Paris VI and from FU Berlin








MyoGrad project 4

PI Berlin: Carmen Birchmeier, PhD, Prof. – Max Delbrück Center for Molecular
               Medicine
PI Paris:   Frederic Relaix, PhD, Prof. – Institute of Myology, UPMC, Paris 6 /
               Paris Est-Creteil University

Thesis title: Coordinating growth arrest and myogenesis in muscle stem cells: A molecular and cellular analysis

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Maria Chatzifrangkeskou

MyoGrad doctoral student 2013-2016
Date and place of thesis defense:
November 8, 2016 in Paris
Doctoral degree from UPMC, Paris VI and from FU Berlin


MyoGrad project 7

PIs Berlin: Simone Spuler, MD, Prof. – Muscle Research Unit, ECRC, Charité
                and Petra Knaus, PhD, Prof. - Institute for Chemistry and
                Biochemistry, Freie Universität Berlin
PIs Paris:  Gisèle Bonne, PhD / Antoine Muchir, PhD – Institut de Institut
                de Myologie, UPMC, Paris 6

Thesis title: Roles of ERK1/2 signaling in LMNA-cardiomyopathy

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Martina Fischer

MyoGrad doctoral student 2013-2017
Date and place of thesis defense:
June 28, 2017 in Berlin
Doctoral degree from UPMC, Paris VI and from FU Berlin

MyoGrad project 7

PIs Berlin: Simone Spuler, MD, Prof. – Muscle Research Unit, ECRC, Charité
                Petra Knaus, PhD, Prof. - Institute of Chemistry and Biochemistry,
                Freie Universität Berlin
PIs Paris:  Gisèle Bonne, PhD and Catherine Coirault, MD, PhD – Institut de
                Myologie, UPMC, Paris 6

Thesis title: Mechanosensing defects and YAP-signaling in LMNA-related congenital muscular dystrophy

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Laurianne Davignon

Laurianne-Davignon-swMyoGrad doctoral student 2010-2015
Date and place of thesis defense:
January 20, 2015 in Paris
Joint doctoral degree from UPMC, Paris VI and from FU Berlin
 







MyoGrad Project 7


PI Berlin: Michael Gotthardt, MD, Prof. – MDC for Molecular Medicine
PI Paris:  Ana Ferreiro, PhD – Institute of Myology, UPMC, Paris 6

Thesis title: Identification and characterization of new genes associated to multiminicore disease

Mina Petkova

Mina-Petkova-swMyoGrad doctoral student 2011-2016
Date and place of thesis defence:
February 5, 2016 in Berlin
Joint doctoral degree from UPMC, Paris 6 and FU Berlin
 
 






MyoGrad Project 1


PI Berlin:                 Markus Schülke-Gerstenfeld, MD, Prof. – NeuroCure
                              Clinical Research Center, Charité
PI Paris / Versailles: Helge Amthor, MD, Prof. – Université de Versailles
                              Saint-Quentin-en-Yvelines

Thesis title: Generation and characterization of a DmdEGFP Reporter Mouse as a Tool to Investigate Dystrophin Expression

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Jürgen Stumm

Jurgen-Stumm-swMyoGrad doctoral student 2011-2016
Date and place of defence:
July 11, 2016 in Berlin
Doctoral degree from FU Berlin
 
 






MyoGrad Project 8

PI Berlin: Sigmar Stricker, PhD, Prof. – Institute of Chemistry and Biochemistry,
              Freie Universität Berlin
PI Paris:  Delphine Duprez, PhD – Developmental Biology, UPMC, Paris 6
              David Sassoon, PhD, Prof. - Myology Group, INSERM, UPMC, Paris 6

Thesis title: The role of Osr1 in postnatal muscle development and muscle regeneration

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Esma Ziat

MyoGrad doctoral student 2011-2015
Date and place of thesis defense:
October 14, 2015 in Paris
Doctoral degree from UPMC Paris VI
 
 
MyoGrad Project 7

PI Berlin: Simone Spuler, MD, Prof. - Muscle Research Unit, ECRC, Charité
PI Paris:  Gisèle Bonne, PhD – Institute of Myology, UPMC, Paris 06

Thesis title:  Emery-Dreifuss muscular dystrophy-related FHL1 gene mutations: study of molecular and functional consequences in striated muscle

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Helena Escobar Fernandez

Helena-Escobar-swMyoGrad doctoral student 2011-2015
Date and place of thesis defense:
November 18, 2015 in Berlin
Doctoral degree from FU Berlin
 







MyoGrad Project 6

PI Berlin: Simone Spuler, MD, Prof. – Muscle Research Unit, ECRC, Charité
              Zsuzsanna Izsvak, PhD - Max Delbrück Center for Molecuar Medicine
PI Paris:  Luis Garcia, PhD – Université de Versailles Saint-Quentin-
              en-Yvelines

Thesis title: A cell-based gene therapy approach for dysferlinopathy using Sleeping Beauty transposon

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Joana Esteves de Lima

Joana-Lima-swMyoGrad doctoral student 2011-2015
Date and place of thesis defense:
September 28, 2015 in Paris
Joint doctoral degree from UPMC, Paris VI and from FU Berlin
 







MyoGrad Project 4


PI Berlin: Carmen Birchmeier, PhD, Prof. – MDC for Molecular Medicine
PI Paris:  Delphine Duprez, PhD – Developmental Biology, UPMC, Paris 6
           

Thesis title: Link between signaling pathways, cell cycle, and mechanical forces during foetal myogenesis

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Pedro Vallecillo Garcia

Pedro-Vallecillo-swMyoGrad doctoral student 2011-2015
Date and place of thesis defense:
September 30, 2015 in Berlin
Joint doctoral degree from UPMC, Paris VI and from FU Berlin
 







MyoGrad Project 8

PI Berlin: Sigmar Stricker, PhD, Prof. – Institute of Chemistry and Biochemistry,
              Freie Universität Berlin
PI Paris:  Delphine Duprez, PhD – Developmental Biology, UPMC, Paris 6
          

Thesis title
:Function of the transcription factor Odd skipped related 1 (Osr 1) in the connective tissue-mediated control of muscle formation

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Mickael Orgeur

Mickael-Orgeur-swMyoGrad doctoral student 2012-2016
Date and place of thesis defense:
September 26, 2016 in Paris
Joint doctoral degree from UPMC, Paris VI and from FU Berlin
 







MyoGrad Project 8

PI Berlin: Sigmar Stricker, PhD, Prof. – Institute for Chemistry and Biochemistry,
              Freie Universität Berlin
PI Paris:  Delphine Duprez, PhD – Developmental Biology, UPMC, Paris 6
          

Thesis Title
:Transcriptional regulatory network underlying connective tissue differentiation during limb development

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William Roman

William-Roman-swMyoGrad doctoral student 2012-2016
Date and place of thesis defense:
September 27, 2016 in Paris
Joint doctoral degree from UPMC, Paris VI and from FU Berlin
 







MyoGrad Project 6


PI Berlin: Simone Spuler, MD, Prof – Muscle Research Group, ECRC, Charité
              Jan Schmoranzer, PhD - Leipniz Institute for Molecuar Pharmacology
PI Paris:  Edgar Gomes, PhD – Institute of Myology, UPMC, Paris 6

Thesis title: Positioning nuclei at the periphery of skeletal muscle cells

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Petra Gimpel

Petra Gimpel swMyoGrad doctoral student 2013-2017
Date and place of thesis defense:
September 4, 2017 in Berlin
Joint doctoral degree from UPMC, Paris 6 and from FU Berlin
 







MyoGrad Project 6


PI Berlin: Simone Spuler, MD, Prof. – Muscle Research Unit, ECRC, Charité
              Jan Schmoranzer, PhD - Leipniz Institute for Molecuar Pharmacology
PI Paris:  Edgar Gomes, PhD – Institute of Myology, UPMC, Paris 6

Thesis title: Mechanism of non-centrosomal MTOC formation at the nucleus in muscle cells

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Sonya Nassari

MyoGrad doctoral student 2013-2017
Date and place of thesis defense:
September 2, 2017 in Paris
Doctoral degree from UPMC, Paris VI
 

MyoGrad Project 8

PI Berlin: Sigmar Stricker, PhD, Prof. – Institute for Chemistry and Biochemistry,
              Freie Universität Berlin
PI Paris:  Delphine Duprez, PhD – Developmental Biology, UPMC, Paris 6
          

Thesis title
: The contribution of connective tissues to muscle morphogenesis: an unexpected role for CXCL12 and CXCL14 chemokines

Abstract: During development, skeletal muscle morphogenesis is an important step to provide proper function of the musculoskeletal system. This process is partially driven through proliferation and differentiation capacities of muscle progenitors cells, but not totally. It has been shown that signals coming from adjacent tissues have a significant role in in the formation of muscle.
The Muscle Connective Tissue (MCT) has been highlighted as an important actor of muscle morphogenesis. Indeed, different transcription factors, specifically expressed in the MCT have been characterized as regulators of muscle morphogenesis. The Zinc Finger transcription factor Odd-Skipped-related 1 (Osr1), that is expressed in the MCT, is involved in cardiac, head and limb muscle formation, and has been shown to negatively regulate limb muscle development (Stricker et al., 2006, Gene expression patterns). So far, no MCT-secreted molecule has been shown to regulate muscle formation. Previously it has been demonstrated that the chemokine CXCL12 is expressed in the MCT. Interestingly, one receptor of CXCL12, CXCR7, is expressed in myogenic cells. Moreover, preliminary data on chick mass highlighted CXCL12 as a putative downstream target gene of Osr1. We suggest that the chemokine CXCL12 might be a signal produced by the Muscle Connective Tissue to act on myogenic cells expressing the CXCR7 receptor.
The aim of this PhD project is to assess the involvement of CXCL12/CXCR7 signaling in connective tissue-mediated control of muscle morphogenesis using chick embryo as model.

Coline Macquart

Coline MacquartMyoGrad doctoral student 2014-2017
Date and place of thesis defense:
December 14, 2017 in Paris
Joint doctoral degree from UPMC, Paris VI and from FU Berlin







MyoGrad project 7

PI Berlin: Michael Gotthardt, MD, Prof. – Max Delbrück Center for Molecular
              Medicine
PI Paris:  Antoine Muchir, PhD – Institut de Myologie, UPMC, Paris 06

Thesis title: Role of gap junctional protein connexion-43 in the cardiac disease caused by mutations in the gene encoding A-typ lamins

Elja Schirwis

Elja-SchirwisMyoGrad doctoral student 2010-2014
Date and place of thesis defense:
March 24, 2014 in Paris
Joint doctoral degree from UPMC, Paris VI and from FU Berlin








MyoGrad Project 4


PI Berlin: Carmen Birchmeier, PhD Prof – MDC for Molecular Medicine
PI Paris:  Helge Amthor, MD, Prof. – Université de Versailles Saint-Quentin-
              en-Yvelines

Thesis title: Skeletal muscle growth and maintenance depend on BMP signaling

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