Simone Spuler, MD, Prof.

s-spuler-portrait-neuScientific Leader of Clinical Research Group (KFO 192), Head of Institute for Muscle Sciences and University Outpatient Clinic for Muscle Disorders
MyoGrad Speaker
Program Coordinator Collège Doctorale franco-allemand





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Phone: +49 30 450 540501
Fax:     +49 30 450 540914


Experimental and Clinical Research Center (ECRC)
Charité - Universitätsmedizin Berlin, Campus Buch


Fields of responsibility and projects
Leader Institute for Muscle Sciences and University Outpatient Clinic for Muscle Disorders
Scientific leader: KFO 192 – Regulation and dysregulation of skeletal muscle growth
MyoGrad Speaker, Berlin – International Research Training Group for Myology Berlin-Paris
MyoGrad Subproject Speaker P6: Development of therapies
Member Selection committee "International Graduate Program Medical Neurosciences" Charité - Universitätsmedizin Berlin
Member Research committee Charité - Universitätsmedizin Berlin
Chairwoman Training program for clinicians (KAP) Charité - Universitätsmedizin Berlin


Scientific Background

Education

1980-1986
Medical School, University of Würzburg, Germany, Rotations at Harvard
Medical School and Johns Hopkins Medical School, U.S.A.

1986-1987
Internship, Internal Medicine, Universitätskrankenhaus Eppendorf, Hamburg, Director: Prof. Dr. H. Greten

1989-1994
Residency, Dept. of Neurology, Klinikum Großhadern München, Director: Prof. Dr. Th. Brandt in cooperation with Max-Planck-Institut of Psychiatry, Div. Neuroimmunology, Martinsried, Director: Prof. Dr. H. Wekerle


Career/Employment
1995
Faculty rank (Habilitation) in Neurology

2002-2007
Docent (C2): Dept. of Neurology, Charité - Universitätsmedizin Berlin, Director: Prof. Dr. K.M. Einhäupl

08/2007-
Head of Institute for Muscle Sciences, Experimental and Clinical Research Center, Charité and Max Delbrück Center for Molecular Medicine, Berlin


Honors, Awards, Fellowships
1987-1989
DFG Research Stipend, Laboratory of Mucosal Immunology, University of California, San Diego, La Jolla, U.S.A.

1995-1997
Clinical Fellowship Neuromuscular Diseases, Mayo Clinic, Rochester, MN, U.S.A., Director: Dr. Andrew G. Engel

2002, 2005, 2012
Teaching Award Medical Neurosciences Charité - Universitätsmedizin Berlin

2006
Mayo Alumni Research Award

2007-2015
Scientific leader of Clinical Research Group (KFO 192) "Regulation and dysregulation of skeletal muscle growth"

2010
Professorship, Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin

Collaborative Research Projects (selection)
Funding organisation German Research Foundation (DFG)
Project title Regulation and dysregulation of skeletal muscle growth (KFO192), P6: Role of myostatin on dysferlinopathy
Function Scientific leader and principle investigator of P6
Speaker Charité - Universitätsmedizin Berlin
Project Period 2007-2014

Funding organisation Federal Ministry for Research and Education (BMBF)
Project title SatNet, Fate determination and maintenance of muscle stem cells, P 4 (with Prof. Markus Schülke-Gerstenfeld)
Speaker Freie Universität Berlin
Function Project leader
Project Period 2010-2012

Funding organisation German Research Foundation (DFG)
Project title MyoGrad - International Research Training Group GRK 1631
Project 6: Dysferlinopathy – Sarcolemmal morphology and consequences of gene repair
Speaker Freie Universität and Humboldt Universität Berlin
Function Speaker Berlin and leader of P6
Project Period 2010-2014

Funding organisation German Research Foundation (DFG)
Project title Analysis of nutrient and endocrine signals modifying homeostasis and adipogenesis, P4 (with Prof. Joachim Spranger)
Speaker Charité - Universitätsmedizin Berlin
Function Project leader
Project Period 2010-2014

Funding organisation Université Franco-Allemande
German-French doctoral program
Function Scientific Leader together with Prof. Helge Amthor (UVSQ)
Project Period 2011-2016

Funding organisation Université Franco-Allemande
German-French Summer Schools 2011, 2012, 2013, 2014, 2015
Function Scientific Leader together with Prof. Helge Amthor (UVSQ)


Ten selected Publications
Knoblauch H*, Schöwel V*, Kress W, Kassner U, Spuler S. (2010) Another side to statin related side effects. Ann Int Med, 152: 478-479 (*contributed equally)

Knoblauch H, Geier C, Adams S, Budde B, Rudolph A, Schulz-Menger J, Spuler A, Ben Yaou R, Nürnberg, P, Voit T, Bonne G, Spuler S. (2010) Contractures and hypertrophic cardiomyopathy in a novel FHL1 mutation. Ann Neurol, 67: 136-140

Schmidt S, Vieweger A, Obst M, Gross V, Mueller S, Steinbrink J, Gutberlet M, Misselwitz B, Luedemann L, Spuler S. (2009) Gadofluorine M enhanced MR imaging enables differentiation of diseased from non diseased muscle in a model of dysferlin-deficient muscular dystrophy in mice. Radiology. 250(1):87-94.

Spuler S, Carl M, Zabojszcza J, Straub V, Bushby K, Moore SA, Bähring S, Wenzel K, Vinkemeier U, Rocken C. (2008) Dysferlin deficient muscular dystrophy features amyloidosis. Ann Neurol. 63(3):323-328.

Spuler S, Kalbhenn T, Zabojszcza J, van Landeghem FKH, Ludtke A, Wenzel K, Koehnlein M, Schuelke M, Lüdemann L, Schmidt HH. (2007) Muscle and nerve pathology in Dunnigan familial partial lipodystrophy. Neurology 68(9):677-683.

Wenzel K, Carl M, Perrot A, Zabojszcza J, Assadi M, Ebeling M, Robinson PN, Kress W, Osterziel KJ, Spuler S. (2006) Novel sequence variants in dysferlin-deficient muscular dystrophy leading to mRNA decay and possible C2-domain misfolding. Human Mutation. 27(6):599-600.

Wenzel K, Zabojszcza J, Carl M, Taubert S, Lass A, Harris CL, Ho M, Schulz H, Hummel O, Hubner N, Osterziel KJ, Spuler S. (2005) Increased susceptibility to complement attack due to downregulation of decay accelerating factor/CD55 in dysferlin-deficient muscular dystrophy. J Immunology. 175: 6219-6225.

Spuler S; Emslie-Smith AM; Engel AG (1998) Amyloid myopathy: An underdiagnosed entity. Ann. Neurol. 43: 719-728.

Schönbeck S; Padberg F; Hohlfeld R; Wekerle H. (1992) Transplantation of thymic autoimmune microenvironment to SCID mice: A new model of myasthenia gravis J. Clin. Invest.; 90: 245-250

Schoenbeck S; Hammen MJ; Kagnoff MF. (1989) Vicia Villosa adherence separates freshly isolated T helper cells into interleukin 5 or interleukin 2 producing subsets J. Exp. Med., 169: 1491–1496