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Scientific articles illustrated on video






Publications by MyoGrad students

* MyoGrad student

2017

Stantzou A*, Ueberschlag-Pitiot V, Thomasson R, Furling D, Bonnieu A, Amthor H, Ferry A.The effect of constitutive inactivation of the myostatin gene on the gain in muscle strength during postnatal growth in two murine models. Muscle Nerve. 2017 Feb;55(2):254-261. doi: 10.1002/mus.25220. Epub 2016 Nov 12.

2016

Ziat E*, Mamchaoui K, Beuvin M, Nelson I, Azibani F, Spuler S, Bonne G, Bertrand AT. FHL1B Interacts with Lamin A/C and Emerin at the Nuclear Lamina and is Misregulated in Emery-Dreifuss Muscular Dystrophy. J Neuromuscul Dis. 2016 Nov 29;3(4):497-510. DOI: 10.3233/JND-160169.

Esteves de Lima J*, Bonnin MA, Birchmeier C, Duprez D. Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis. Elife. 2016 Aug 24;5. pii: e15593.

Bhattarai S*, Ghannam K, Krause S, Benveniste O, Marg A, de Bruin G, Xin BT, Overkleeft HS, Spuler S, Stenzel W, Feist E. The immunoproteasomes are key to regulate myokines and MHC class I expression in idiopathic inflammatory myopathies. J Autoimmun. 2016 Dec;75:118-129. doi: 10.1016/j.jaut.2016.08.004. Epub 2016 Aug 10.

Petkova MV*, Morales-Gonzales S, Relizani K, Gill E, Seifert F, Radke J, Stenzel W, Garcia L, Amthor H, Schuelke M.Characterization of a Dmd (EGFP) reporter mouse as a tool to investigate dystrophin expression. Skelet Muscle. 2016 Jul 5;6:25.

Alonso-Martin S, Rochat A, Mademtzoglou D*, Morais J, de Reyniès A, Auradé F, Chang TH, Zammit PS, Relaix F. Gene Expression Profiling of Muscle Stem Cells Identifies Novel Regulators of Postnatal Myogenesis. Front Cell Dev Biol. 2016 Jun 21;4:58.

Buclez PO, Dias Florencio G*, Relizani K*, Beley C, Garcia L, Benchaouir R. Rapid, scalable, and low-cost purification of recombinant adeno-associated virus produced by baculovirus expression vector system. Mol Ther Methods Clin Dev. 2016 May 11;3:16035. doi: 10.1038/mtm.2016.35. eCollection 2016.

Chatzifrangkeskou M*, Le Dour C, Wu W, Morrow JP, Joseph LC, Beuvin M, Sera F, Homma S, Vignier N, Mougenot N, Bonne G, Lipson KE, Worman HJ, Muchir A. ERK1/2 directly acts on CTGF/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A/C gene. Hum Mol Genet. 2016 Apr 30. pii: ddw090. [Epub ahead of print]

Davignon L*, Chauveau C, Julien C, Dill C, Duband-Goulet I, Cabet E, Buendia B, Lilienbaum A, Rendu J, Minot MC, Guichet A, Allamand V, Vadrot N, Fauré J, Odent S, Lazaro L, Leroy JP, Marcorelles P, Dubourg O, Ferreiro A. The transcription coactivator ASC-1 is a regulator of skeletal myogenesis, and its deficiency causes a novel form of congenital muscle disease. Hum Mol Genet. 2016 Apr 15;25(8):1559-73.

Béchir N, Pecchi É, Relizani K*, Vilmen C, Le Fur Y, Bernard M, Amthor H, Bendahan D, Giannesini B. Mitochondrial impairment induced by postnatal ActRIIB blockade does not alter function and energy status in exercising mouse glycolytic muscle in vivo. Am J Physiol Endocrinol Metab. 2016 Apr 1;310(7):E539-49.

Fischer M*, Rikeit P, Knaus P, Coirault C.YAP-Mediated Mechanotransduction in Skeletal Muscle. Front Physiol. 2016 Feb 16;7:41. doi: 10.3389/fphys.2016.00041. eCollection 2016. Review.

Moshourab R, Palada V*, Grunwald S, Grieben U, Lewin G, Spuler S. A Molecular Signature of Myalgia in Myotonic Dystrophy 2, EBioMedicine. 2016;7:205-11.

Knierim E, Hirata H, Wolf NI, Morales-Gonzalez S, Schottmann G, Tanaka Y, Rudnik-Schöneborn S, Orgeur M*, Zerres K, Vogt S, van Riesen A, Gill E, Seifert F, Zwirner A, Kirschner J, Goebel HH, Hübner C, Stricker S, Meierhofer D, Stenzel W, Schuelke M. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. Am J Hum Genet. 2016 Mar 3;98(3):473-89.

Escobar H*, Schoewel V, Spuler S, Marg A†, Izsvák Z†. Full-length dysferlin transfer by the hyperactive Sleeping Beauty transposase restores dysferlin-deficient muscle. Mol Ther Nucleic Acids. 2016 Jan 19;5:e277. †contributed equally

2015

Dias Florencio G*, Precigout G, Beley C, Buclez PO, Garcia L, Benchaouir R. Simple downstream process based on detergent treatment improves yield and in vivo transduction efficacy of adeno-associated virus vectors. Mol Ther Methods Clin Dev. 2015 Jul 15;2:15024.

Bourgeois A*, Esteves de Lima J*, Charvet B, Kawakami K, Stricker S, Duprez D. Stable and bicistronic expression of two genes in somite- and lateral plate-derived tissues to study chick limb development. BMC Dev Biol. 2015 Oct 30;15(1):39.

Zalc A*, Relaix F. [Pax3 and Pax7 play essential safeguard functions against environmental stress-induced birth defects]. Med Sci (Paris). 2015 Aug-Sep;31(8-9):723-5.

Du Bois P, Pablo Tortola C*, Lodka D, Kny M, Schmidt F, Song K, Schmidt S, Bassel-Duby R, Olson EN3, Fielitz J. Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression. Circ Res. 2015 Aug 14;117(5):424-36.

Berkholz J*, Orgeur M*, Stricker S, Munz B. skNAC and Smyd1 in transcriptional control. Exp Cell Res. 2015 Aug 15;336(2):182-91.

Philippi S*, Lorain S, Beley C, Peccate C, Précigout G, Spuler S, Garcia L. Dysferlin rescue by spliceosome-mediated pre-mRNA trans-splicing targeting introns harbouring weakly defined 3’ splice sites. Hum Mol Genet. 2015 Jul 15;24(14):4049-60.

Zhu L, Malatras A*, Thorley M*, Aghoghogbe I, Mer A, Duguez S, Butler-Browne G, Voit T, Duddy W. CellWhere: graphical display of interaction networks organized on subcellular localizations. Nucleic Acids Res. 2015 Jul 1;43(W1):W571-5.

Thorley M*, Malatras A*, Duddy W*, Le Gall L, Mouly V, Butler-Browne G, Duguez S. Changes in communication between muscle stem cells and their environment with aging. J Neuromuscul Diseases. 2015. 2(3), pp. 205-217.

Timmel T†, Kunz S*†, Seifert F, Schuelke M, Spuler S. Cavin 1 function does not follow caveolar morphology. Am J Physiol Cell Physiol. 2015 Jun 15;308(12):C1023-30.
† shared first authorship

Zalc A*, Rattenbach R, Auradé F, Cadot B, Relaix F. Pax3 and Pax7 Play Essential Safeguard Functions against Environmental Stress-Induced Birth Defects. Dev Cell. 2015 Apr 6;33(1):56-66.

Chatzifrangkeskou M*, Bonne G, Muchir A. Nuclear envelope and striated muscle diseases. Curr Opin Cell Biol. 2015 Feb;32:1-6.

2014

Berkholz J*, Kuzyniak W, Hoepfner M, Munz B. Overexpression of the skNAC gene in human rhabdomyosarcoma cells enhances their differentiation potential and inhibits tumor cell growth and spreading. Clin Exp Metastasis. 2014 Dec;31(8):869-79.

Grifone R, Xie X, Bourgeois A*, Saquet A, Duprez D, Shi DL. The RNA-binding protein Rbm24 is transiently expressed in myoblasts and is required for myogenic differentiation during vertebrate development. Mech Dev. 2014 Nov;134:1-15.

Marg A, Escobar H*, Gloy S, Kufeld M, Zacher J, Spuler A, Birchmeier C, Izsvák Z, Spuler S. Human satellite cells have regenerative capacity and are genetically manipulable. J Clin Invest. 2014 Oct 1;124(10):4257-65.

Schmidt F, Kny M, Zhu X, Wollersheim T, Persicke K, Langhans C*, Lodka D, Kleber C, Weber-Carstens S, Fielitz J. The E3 ubiquitin ligase TRIM62 and inflammation-induced skeletal muscle atrophy.Crit Care. 2014 Sep 29;18(5):545.

Falcone S, Roman W*, Hnia K, Gache V, Didier N, Lainé J, Auradé F, Marty I, Nishino I, Charlet-Berguerand N, Romero NB, Marazzi G, Sassoon D, Laporte J, Gomes ER. N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy. EMBO Mol Med. 2014 Sep 28;6(11):1455-75.

Berkholz J*, Michalick L, Munz B. The E3 SUMO ligase Nse2 regulates sumoylation and nuclear-to-cytoplasmic translocation of skNAC-Smyd1 in myogenesis. J Cell Sci. 2014 Sep 1;127(Pt 17):3794-804.

Esteves de Lima J*, Bonnin MA, Bourgeois A*, Parisi A, Le Grand F, Duprez D. Specific pattern of cell cycle during limb fetal myogenesis. Dev Biol. 2014 Aug 15;392(2):308-23.

Ghannam K, Martinez-Gamboa L, Spengler L, Krause S, Smiljanovic B, Bonin M, Bhattarai S*, Grützkau A, Burmester GR, Häupl T, Feist E. Upregulation of immunoproteasome subunits in myositis indicates active inflammation with involvement of antigen presenting cells, CD8 T-cells and IFNΓ. PLoS One. 2014 Aug 6;9(8):e104048.

Zalc A*, Hayashi S, Auradé F, Bröhl D, Chang T, Mademtzoglou D*, Mourikis P, Yao Z, Cao Y, Birchmeier C, Relaix F. Antagonistic regulation of p57kip2 by Hes/Hey downstream of Notch signaling and muscle regulatory factors regulates skeletal muscle growth arrest. Development. 2014 Jul;141(14):2780-90.

Mouisel E, Relizani K*, Mille-Hamard L, Denis R, Hourdé C, Agbulut O, Patel K, Arandel L, Morales-Gonzalez S, Vignaud A, Garcia L, Ferry A, Luquet S, Billat V, Ventura-Clapier R, Schuelke M, Amthor H. Myostatin is a key mediator between energy metabolism and endurance capacity of skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2014 Aug 15;307(4):R444-54.

Relizani K*, Mouisel E, Giannesini B, Hourdé C, Patel K, Morales Gonzalez S, Jülich K, Vignaud A, Piétri-Rouxel F, Fortin D, Garcia L, Blot S, Ritvos O, Bendahan D, Ferry A, Ventura-Clapier R, Schuelke M, Amthor H. Blockade of ActRIIB signaling triggers muscle fatigability and metabolic myopathy. Mol Ther. 2014 Aug;22(8):1423-33.

Wollersheim T, Woehlecke J, Krebs M, Hamati J, Lodka D, Luther-Schroeder A, Langhans C*, Haas K, Radtke T, Kleber C, Spies C, Labeit S, Schuelke M, Spuler S, Spranger J, Weber-Carstens S, Fielitz J. Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness. Intensive Care Med. 2014 Apr;40(4):528-38.

von Renesse A, Petkova MV*, Lützkendorf S, Heinemeyer J, Gill E, Hübner C, von Moers A, Stenzel W, Schuelke M. POMK mutation in a family with congenital muscular dystrophy with merosin deficiency, hypomyelination, mild hearing deficit and intellectual disability. J Med Genet. 2014 Apr;51(4):275-82.

Langhans C*, Weber-Carstens S, Schmidt F, Hamati J, Kny M, Zhu X, Wollersheim T, Koch S, Krebs M, Schulz H, Lodka D, Saar K, Labeit S, Spies C, Hubner N, Spranger J, Spuler S, Boschmann M, Dittmar G, Butler-Browne G, Mouly V, Fielitz J. Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy. PLoS One. 2014 Mar 20;9(3):e92048.

Mosler S, Relizani K*, Mouisel E, Amthor H, Diel P. Combinatory effects of siRNA-induced myostatin inhibition and exercise on skeletal muscle homeostasis and body composition. Physiol Rep. 2014 Mar 20;2(3):e00262.

Kuss P, Kraft K, Stumm J*, Ibrahim D, Vallecillo-Garcia P*, Mundlos S, Stricker S. Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A. Dev Biol. 2014 Jan 1;385(1):83-93.

2013

Sartori R, Schirwis E*, Blaauw B, Bortolanza S, Zhao J, Enzo E, Stantzou A*, Mouisel E, Toniolo L, Ferry A, Stricker S, Goldberg AL, Dupont S, Piccolo S, Amthor H, Sandri M. BMP signaling controls muscle mass. Nat Genet. 2013 Nov;45(11):1309-18.

Pakula A*, Schneider J, Janke J, Zacharias U, Schulz H, Hübner N, Mähler A, Spuler A, Spuler S, Carlier P, Boschmann M. Altered expression of cyclin A 1 in muscle of patients with facioscapulohumeral muscle dystrophy (FSHD-1). PLoS One. 2013 Sep 3;8(9):e73573.

Lorain S, Peccate C, Le Hir M, Griffith G, Philippi S*, Précigout G, Mamchaoui K, Jollet A, Voit T, Garcia L. Dystrophin rescue by trans-splicing: a strategy for DMD genotypes not eligible for exon skipping approaches. Nucleic Acids Res. 2013 Sep;41(17):8391-402.

Berkholz J*, Zakrzewicz A, Munz B. skNAC depletion stimulates myoblast migration and perturbs sarcomerogenesis by enhancing calpain 1 and 3 activity. Biochem J. 2013 Jul 15;453(2):303-10.

Pascoal S, Esteves de Lima J*, Leslie JD, Hughes SM, Saúde L. Notch signalling is required for the formation of structurally stable muscle fibres in zebrafish. PLoS One. 2013 Jun 28;8(6):e68021.

Lagha M, Mayeuf-Louchart A, Chang T, Montarras D, Rocancourt D, Zalc A*, Kormish J, Zaret KS, Buckingham ME, Relaix F. Itm2a is a Pax3 target gene, expressed at sites of skeletal muscle formation in vivo. PLoS One. PLoS One. 2013 May 1;8(5):e63143.

Hirata H, Nanda I, van Riesen A, McMichael G, Hu H, Hambrock M, Papon MA, Fischer U, Marouillat S, Ding C*, Alirol S, Bienek M, Preisler-Adams S, Grimme A, Seelow D, Webster R, Haan E, MacLennan A, Stenzel W, Yap TY, Gardner A, Nguyen LS, Shaw M, Lebrun N, Haas SA, Kress W, Haaf T, Schellenberger E, Chelly J, Viot G, Shaffer LG, Rosenfeld JA, Kramer N, Falk R, El-Khechen D, Escobar LF, Hennekam R, Wieacker P, Hübner C, Ropers HH, Gecz J, Schuelke M, Laumonnier F, Kalscheuer VM. ZC4H2 mutations are associated with arthrogryposis multiplex congenita and intellectual disability through impairment of central and peripheral synaptic plasticity. Am J Hum Genet. 2013 May 2;92(5):681-95.

Weber-Carstens S, Schneider J, Wollersheim T, Assmann A, Bierbrauer J, Marg A, Al Hasani H, Chadt A, Wenzel K, Koch S, Fielitz J, Kleber C, Faust K, Mai K, Spies CD, Luft FC, Boschmann M, Spranger J, Spuler S. Critical illness myopathy and GLUT4: significance of insulin and muscle contraction. Am J Respir Crit Care Med. 2013 Feb 15;187(4):387-96.

Schirwis E*, Agbulut O, Vadrot N, Mouisel E, Hourdé C, Bonnieu A, Butler-Browne G, Amthor H, Ferry A. The beneficial effect of myostatin deficiency on maximal muscle force and power is attenuated with age. Exp Gerontol. 2013 Feb;48(2):183-90.

2012

Hoogaars WM, Mouisel E, Pasternack A, Hulmi JJ, Relizani K*, Schuelke M, Schirwis E*, Garcia L, Ritvos O, Ferry A, 't Hoen PA, Amthor H. Combined effect of AAV-U7-induced dystrophin exon skipping and soluble activin Type IIB receptor in mdx mice. Hum Gene Ther. 2012 Dec;23(12):1269-79.

Schoewel V, Marg A, Kunz S*, Overkamp T, Carrazedo RS, Zacharias U, Daniel PT, Spuler S. Dysferlin-peptides reallocate mutated dysferlin thereby restoring function. PLoS One. 2012;7(11):e49603.

Bröhl D, Vasyutina E, Czajkowski MT, Griger J*, Rassek C, Rahn HP, Purfürst B, Wende H, Birchmeier C. Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals. Dev Cell. 2012 Sep 11;23(3):469-81.

Meyer SU, Kaiser S, Wagner C, Thirion C, Pfaffl MW. Profound effect of profiling platform and normalization strategy on detection of differentially expressed microRNAs – a comparative study. PLoS One 2012; 7: e38946.

Marg A1, Schoewel V, Timmel T, Schulze A, Shah C, Daumke O, Spuler S. Sarcolemmal repair is a slow process and includes EHD2.Traffic. 2012 Sep;13(9):1286-94.

Bierbrauer J, Koch S, Olbricht C, Hamati J, Lodka D, Schneider J*, Luther-Schröder A, Kleber C, Faust K, Wiesener S, Spies CD, Spranger J, Spuler S, Fielitz J, Weber-Carstens S. Early type II fiber atrophy in intensive care unit patients with nonexcitable muscle membrane. Crit Care Med 2012; 40: 647-50.

Philippi S*, Bigot A, Marg A, Mouly V, Spuler S, Zacharias U. Dysferlin-deficient immortalized human myoblasts and myotubes as a useful tool to study dysferlinopathy. Version 2. PLoS Curr. 2012 Feb 2 [revised 2012 Feb28];4:RRN1298.

Berger F†, Berkholz J†*, Breustedt T, Ploen D, Munz B. Skeletal muscle-specific variant of nascent polypeptide associated complex alpha (skNAC): implications for a specific role in mammalian myoblast differentiation. Eur J Cell Biol. 2012 Feb;91(2):150-5.† shared first authorship

2011

Mamchaoui K, Trollet C, Bigot A, Negroni E, Chaouch S, Wolff A, Kandalla PK, Marie S, Di Santo J, St Guily JL, Muntoni F, Kim J, Philippi S*, Spuler S, Levy N, Blumen SC, Voit T, Wright WE, Aamiri A, Butler-Browne G, Mouly V. Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders. Skelet Muscle. 2011 Nov 1;1:34.

2010

Meyer SU, Pfaffl MW, Ulbrich SE. Normalization strategies for microRNA profiling experiments: a 'normal' way to a hidden layer of complexity? Biotechnol Lett 2010; 32: 1777-88.

 

Events


MyoGrad Journal Club


Wednesdays from 9:00 to 10:00 h


Locations:

Berlin:
MyoGrad Conference Room (3303), Bldg. 46, 2nd floor, Charité Campus Buch, Lindenberger Weg 80,   13125 Berlin

Paris:
Salle 2, Bâtiment Babinski, Institut de Myologie, 47-83, bd de l'Hôpital, 75651 Paris

Online participation: Click on the following link:
https://webconf.vc.dfn.de/myogradjournalclub/ and dial
: +40 30 450 540 520


Upcoming Doctoral Disputations



To be announced.



Foundation Gisela Krebs


The Foundation Gisela Krebs was initiated in February 2016 to foster research on muscle stem cells and to support development of biotherapies in the field of neuromuscular diseases. The funds are exclusively dedicated to provide salaries for early career scientists (Ph.D. students, MD doctoral students, 1st year post-docs). The foundation will exist in its present form until 2026.

For further information please contact Prof. Dr. Simone Spuler at This email address is being protected from spambots. You need JavaScript enabled to view it.

Publications Clinical Research Group 192

2007- 2015

Only peer-reviewed paper published or accepted for publication are listed here.

Du Bois P, Pablo Tortola C*, Lodka D, Kny M, Schmidt F, Song K, Schmidt S, Bassel-Duby R, Olson EN3, Fielitz J. Angiotensin II Induces Skeletal Muscle Atrophy by Activating TFEB-Mediated MuRF1 Expression. Circ Res. 2015 Aug 14;117(5):424-36.

Timmel T†, Kunz S*†, Seifert F, Schuelke M, Spuler S. Cavin 1 function does not follow caveolar morphology. Am J Physiol Cell Physiol. 2015 Jun 15;308(12):C1023-30.
† shared first authorship

Marg A, Escobar H, Gloy S, Kufeld M, Zacher J, Spuler A, Birchmeier C, Izsvák Z, Spuler S. Human satellite cells have regenerative capacity and are genetically manipulable. J Clin Invest. 2014 Oct 1;124(10):4257-65. 

Schmidt F, Kny M, Zhu X, Wollersheim T, Persicke K, Langhans C*, Lodka D, Kleber C, Weber-Carstens S, Fielitz J. The E3 ubiquitin ligase TRIM62 and inflammation-induced skeletal muscle atrophy.Crit Care. 2014 Sep 29;18(5):545.


Koch S, Wollersheim T, Bierbrauer J, Haas K, Mörgeli R, Deja M, Spies CD, Spuler S, Krebs M, Weber-Carstens S. Long term Recovery in Critical Illness Myopathy is complete, contrary to Polyneuropathy. Muscle Nerve. 2014 Sep;50(3):431-6.

Grounds MD, Terrill JR, Radley-Crabb HG, Robertson T, Papadimitriou J, Spuler S, Shavlakadze T. Lipid accumulation in dysferlin-deficient muscles. Am J Pathol. 2014 Jun;184(6):1668-76.

Wollersheim T, Woehlecke J, Krebs M, Hamati J, Lodka D, Luther-Schroeder A, Langhans C, Haas K, Radtke T, Kleber C, Spies C, Labeit S, Schuelke M, Spuler S, Spranger J, Weber-Carstens S, Fielitz J. Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness. Intensive Care Med. 2014 Apr;40(4):528-38.

Timmel T, Schuelke M, Spuler S. Identifying Dynamic Membrane Structures with Atomic-Force Microscopy and Confocal Imaging. Microscopy and Microanalysis. 2014 Apr;20(2):514-20.

Langhans C, Weber-Carstens S, Schmidt F, Hamati J, Kny M, Zhu X, Wollersheim T, Koch S, Krebs M, Schulz H, Lodka D, Saar K, Labeit S, Spies C, Hubner N, Spranger J, Spuler S, Boschmann M, Dittmar G, Butler-Browne G, Mouly V, Fielitz J. Inflammation-induced acute phase response in skeletal muscle and critical illness myopathy. PLoS One. 2014 Mar 20;9(3):e92048.

Pakula A, Schneider J, Janke J, Zacharias U, Schulz H, Hübner N, Mähler A, Spuler A, Spuler S, Carlier P, Boschmann M. Altered expression of cyclin A 1 in muscle of patients with facioscapulohumeral muscle dystrophy (FSHD-1). PLoS One. 2013 Sep 3;8(9):e73573.

Raith M, Valencia RG, Fischer I, Orthofer M, Penninger JM, Spuler S, Rezniczek GA, Wiche G. Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by estabilizing microtubule networks in mdx myofibers. Skelet Muscle. 2013 Jun 12;3(1):14.

Weber-Carstens S, Schneider J, Wollersheim T, Assmann A, Bierbrauer J, Marg A, Al Hasani H, Chadt A, Wenzel K, Koch S, Fielitz J, Kleber C, Faust K, Mai K, Spies CD, Luft FC, Boschmann M, Spranger J, Spuler S. Critical illness myopathy and GLUT4 – significance of insulin and muscle contraction. Am J Resp Crit Care Med. 2013 Feb 15;187(4):387-96.

Schoewel V, Marg A, Kunz S, Overkamp T, Siegert Carrazedo R, Zacharias U, Daniel PT, Spuler S. Dysferlin-Peptides Reallocate Mutated Dysferlin Thereby Restoring Function. PloS one. 2012;7(11):e49603.

Marg A, Schoewel V, Timmel T, Schulze A, Shah C, Daumke O, Spuler S. Sarcolemmal repair is a slow process and includes EHD2. Traffic. 2012 Sep;13(9):1286-94.

Philippi S, Bigot A, Marg A, Mouly V, Spuler S, Zacharias U Dysferlin-deficient immortalized human myoblasts and myotubes as a useful tool to study dysferlinopathy. PLoS Curr. 2012; 4: RRN1298.

Zacharias U., Purfürst B., Schöwel V., Morano I., Spuler S., and Haase H.: Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release. J Muscle Res Cell Motil. 2011; 32(4-5): 271-80.

Rajab A, Straub V, McCann LJ, Seelow D, Varon R, Barresi R, Schulze A, Lucke B, Lützkendorf S, Karbasiyan M, Bachmann S, Spuler S, Schuelke M. Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. PLoS Genet. 2010 Mar 12;6(3):e1000874.

Knoblauch H*, Schoewel V*, Kress W, Rosada A, Spuler S. Another side to statin-related side effects. Ann Intern Med. 2010 Apr 6;152(7):478-9. Erratum in: Ann Intern Med. 2010 May 18;152(10):688. (*contributed equally)

Boschmann M, Engeli S, Moro C, Luedtke A, Adams F, Gorzelniak K, Rahn G, Mähler A, Dobberstein K, Krüger A, Schmidt S, Spuler S, Luft FC, Smith SR, Schmidt HHJ, Jordan J. LMNA mutations, skeletal muscle lipid metabolism, and insulin resistance. J Clin Endocrinol Metab. 2010 Apr;95(4):1634-43.

Knoblauch H, Geier C, Adams S, Budde B, Rudolph A, Zacharias U, Schulz-Menger J, Spuler A, Ben Yaou R, Nürnberg, P, Voit T, Bonne G, Spuler S. Contractures and hypertrophic cardiomyopathy in a novel FHL1 mutation. Ann Neurol, 2010; 67:136–140 .

Utz W, Schmidt S, Schulz-Menger J, Luft FC, Spuler S. Cardiac involvement in sporadic inclusion body myositis. Circulation, 2010; 121: 706-8.

Weber-Carstens S, Koch S, Spuler S, Spies CD, Bubser F, Wernecke KD, Deja M. Nonexcitable muscle membrane predicts intensive care unit-acquired paresis in mechanically ventilated, sedated patients. Crit Care Med, 2009, 37: 2632-2637.

Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H, Lüscher TF, Bart B, Banasiak W, Niegowska J, Kirwan BA, Mori C, von Eisenhart Rothe B, Pocock SJ, Poole-Wilson PA, Ponikowski P; FAIR-HF Trial Investigators. Ferric carboxymaltose in patients with heart failure and iron deficiency. N Engl J Med. 2009 Dec 17;361(25):2436-48.

Spuler S, Krug H, Klein C, Chaure-Medialdea I, Jakob W, Ebersbach G, Gruber D, Hoffmann KT, Trottenberg T, Kupsch A. Myopathy causing camptocormia in idiopathic Parkinson's disease: a multidisciplinary approach. Mov Disord. 2010 Apr 15;25(5):552-9.

Ottenheijm CA, Hidalgo C, Rost K, Gotthardt M, Granzier H. Altered contractility of skeletal muscle in mice deficient in titin's M-band region. J Mol Biol. 2009 Oct 16;393(1):10-26.

Szabo T, von Haehling S, Habedank D, Rauchhaus M, Lainscak M, Sandek A, Schefold J, Anker SD, Doehner W. Usefulness of minimal modelling to assess impaired insulin sensitivity in patients with chronic heart failure. Int J Cardiol. 2011 Feb 17;147(1):47-51.

Mai K, Andres J, Biedasek K, Weicht J, Bobbert T, Sabath M, Meinus S, Reinecke F, Möhlig M, Weickert MO, Clemenz M, Pfeiffer AF, Kintscher U, Spuler S, Spranger J. Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21. Diabetes 2009 58:1532-8.

Spuler S, Carl M, Zabojszcza J, Straub V, Bushby K, Moore SA, Bähring S, Wenzel K, Vinkemeier U, Rocken C. Dysferlin deficient muscular dystrophy features amyloidosis. Ann Neurol, 2008, 63: 323-328.

Geier C, Gehmlich K, Ehler E, Hassfeld E, Perrot A, Hayess K, Cardim N, Wenzel K, Erdmann B, Krackhardt F, Posch M, Bublak A, Nägele H, Scheffold T, Chien KR, Dietz R, Osterziel KJ, Spuler S, Fuerst DO, Nürnberg P, Özcelik C. Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy. Hum Mol Gen. 2008, 17: 2753-2765.

Schmidt S, Vieweger A, Obst M, Gross V, Mueller S, Steinbrink J, Gutberlet M, Misselwitz B, Luedemann L, Spuler S. Gadofluorine M enhanced MR imaging enables differentiation of diseased from non diseased muscle in a model of dysferlin-deficient muscular dystrophy in mice. Radiology, 2009, 250: 87-94.

Marg A, Meyer T, Vigneron M, Vinkemeier U. Microinjected antibodies interfere with protein nucleoplasmic shuttling by distinct molecular mechanisms. Cytometry A, 2008, 73A: 1128-1140.

Wenzel K, Geier C, Qadri F, Hubner N, Schulz H, Erdmann B, Gross V, Bauer D, Dechend R, Dietz R, Osterziel KJ, Spuler S*, Ozcelik C* (*contributed equally) Dysfunction of dysferlin-deficient hearts. J Mol Med, 2007, 85: 1203-1214.

Kategoriebezeichnung

Hier sollte der jeweilige Bereich oder die Kategorie erklärt werden, wenn es sich um einen Beitrag handelt oder keine Liste oder Reihe dargestellt werden kann.

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Application steps

In order to apply for the program, please follow the steps below:

  1. Download, fill out and sign the application form from the MyoGrad website
  2. Prepare the following documents:
    • Curriculum Vitae
    • Letter of intent. This letter should include a statement about the interest in the research field as well as remarks on the specific interest in the international program involving Germany (Berlin) and France (Paris/Versailles)
    • Transcripts (record of study) and degree certificates of your first and final university degrees in your respective field. It is essential that you have (or expect to obtain within the next 6 months) a degree comparable to the German Diploma or a degree corresponding to M2 level or equivalent niveau Bac+5 in France. This can be a Master's Degree with a research thesis, with the final grade being "very good", "excellent" or equivalent.
  3. Provide the addresses of two referees. Please list the full names, addresses and emails of two referees who have agreed to support your application with an evaluation letter. The MyoGrad Office will contact them.
  4. Please submit your complete application in electronic form (a single PDF file) to the MyoGrad Office: This email address is being protected from spambots. You need JavaScript enabled to view it.
  5. For any questions please do not hesitate to contact Susanne Wissler
    +49 30 450 540 504 or This email address is being protected from spambots. You need JavaScript enabled to view it.
  6.  


Important Dates

  Call for applications  To be announced
  Deadline for application  
  Invitation to Interview  
  Interview in Berlin  
  Notification of selected candidates  


Requirements

Students eligible for the program must meet the following criteria:
  • Above average qualifications and grades ("very good" or "excellent") together with a strong interest in scientific issues regarding muscle-related cell and molecular biology or in clinical and scientific aspects of muscle diseases are expected.
  • Applicants are required to have completed (or be in the process of completing) and provide proof of a university degree equivalent to a German Diploma, MSc with written thesis, an MD, a degree corresponding to M2 level or equivalent niveau Bac+5 in France or as listed here. If you have a degree from a country not in the list or if you have any questions do not hesitate to contact the MyoGrad Office.
  • The minimum level of the English required is B2 of the Common European Framework of Reference for Languages (CEFR). TOEFL and GRE scores are welcome. All MyoGrad students will have the opportunity to attend French or German language classes.

Evaluation

A joint evaluation board consisting equally of academic representatives from Université Pierre et Marie Curie UPMC, Paris 6, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Freie Universität Berlin, and Charité Medical Faculty will assess the incoming applications. The following criteria are to be applied:
  • academic excellence of previous scientific work or proposed doctoral thesis
  • previous academic achievement in general
  • academic potential
  • language and soft skills
The selection procedure is highly competitive and only the best candidates will be short-listed for an interview. During the assessment center, board members will examine the candidates’ general scientific knowledge, their intellectual capacity, their motivation for a scientific career in general and the MyoGrad program in particular. Finally, the members of the evaluation board will create a ranking report, according to which the new students will be chosen.

Interview

Students eligible for an interview will
  • give a 10-15 min. presentation about their research experience gained, for example from working on their Master thesis. Alternatively, the applicant may present an outline of the research planned for the PhD thesis.
  • discuss their work with members of the Evaluation Board
  • do interviews with MyoGrad project leaders
  • take part in lab tours
  • meet other candidates and MyoGrad academic staff members at meals.

Scholarship

On the Berlin side MyoGrad PhD or PhD/MD students will receive a monthly grant of EUR 1,365 plus EUR 103 per month for research consumables and a travel benefit for their exchange visits to the partner institution.  
On the Paris/Versailles side MyoGrad PhD students will have a salary of 1.374 EUR per month which includes social insurance and retirement pension.

Imprint

Responsible for the content of these pages
Prof Simone Spuler MD

Muscle Research Unit
Experimental and Clinical Research Center
Medical Faculty of the Charité and
Max Delbrück Center for Molecular Medicine
Lindenberger Weg 80
13125 Berlin, Germany

T: +49 (0) 30 450 540 501
F: +49 (0) 30 450 540 900
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


Webdesign: Regina Eden, Atelier für Erkenntnis und Gestaltung, Berlin
Implementation: Ilja Höltke, Berlin