Project 10 - Caveolae in statin-induced myopathy

Principal investigators 
Elisabeth Steinhagen-Thiessen, MD, Prof and Hans Knoblauch, MD, PhD

Caveolins are a major component of caveolae, which are cholesterol rich invaginations on the plasma membrane. Cholesterol depletion leads to loss of caveolar structure and profound alterations in cell metabolism. Further, through association with the estrogen receptor, caveolae exhibit part of their function in a gender-specific manner. We will elucidate the role of caveolae in statin-induced myopathy by a combined genetic, morphological, and functional approach. The project could have great impact on the understanding of statin myopathy, its treatment and prevention.

The role of caveolae in statin induced Myopathy

Dr. rer. nat. Stefanie Grunwald

In October 2010, I started my first postdoctoral appointment in the group of Simone Spuler. I am involved in project 10 of the Clinical Research Group 192 (P10 in KFO192) with Elisabeth Steinhagen-Thiessen and Hans Knoblauch as principal investigators.